Basic Information
| LncRNA/CircRNA Name | PTPRG-AS1 |
| Synonyms | PTPRG-AS1 |
| Region | GRCh38_3:62260865-62369330 |
| Ensemble | ENSG00000241472 |
| Refseq | NR_038281 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qRT-PCR, Western blotting, Microarray data analysis etc. |
| Sample | NPC tissues and normal adjacent tissues, NPC cell line CNE-2 |
| Expression Pattern | up-regulated |
| Function Description | PTPRG-AS1 and PRC1 were upregulated in NPC, whereas miR-194-3p was downregulated. PTPRG-AS1 was found to specifically bind to miR-194-3p as a competing endogenous RNA and miR-194-3p targets and negatively regulates PRC1. Overexpressed miR-194-3p or silenced PTPRG-AS1 resulted in enhanced sensitivity to radiotherapy and cell apoptosis along with suppressed cell migration, invasion and proliferation in NPC. Furthermore, impaired tumor formation was also caused by miR-194-3p overexpression or PTPRG-AS1 suppression through xenograft tumor in nude mice. |
| Pubmed ID | 30993702 |
| Year | 2019 |
| Title | Long Noncoding RNA PTPRG-AS1 Acts as a microRNA-194-3p Sponge to Regulate Radiosensitivity and Metastasis of Nasopharyngeal Carcinoma Cells via PRC1 |
External Links
| Links for PTPRG-AS1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |