Basic Information
| LncRNA/CircRNA Name | PTENP1-AS |
| Synonyms | NA |
| Region | GRCh38_9:33677268-33688011 |
| Ensemble | ENSG00000281128 |
| Refseq | NR_103745 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi etc. |
| Sample | cell lines (AGS1, MGC803, SGC7901, and MKN45), gastric adenocarcinomas tissues |
| Expression Pattern | up-regulated |
| Function Description | In the present study, we observed a higher level of H19 which sponged out the low level expressed miR-148a leading to the overexpression of its target mRNA DNMT1. In this study, we observed upregulation of PTENP1-AS increased the EGFR and AGO4 level in tumors. In addition, we also observed that lncRNA GAS5 competes with AGO4 for miR-21. Compared to PTENP1-AS, |
| Pubmed ID | 29719612 |
| Year | 2018 |
| Title | Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer. |
External Links
| Links for PTENP1-AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |