Basic Information
| LncRNA/CircRNA Name | PTENP1 |
| Synonyms | PTENP1, PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN |
| Region | GRCh38_9:33673504-33677499 |
| Ensemble | ENSG00000237984 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Cell transfection, Luciferase reporter assay, Cell migration and invasion assay etc. |
| Sample | gastric cancer tissues, cell lines (GES-1, AGS, SGC7901, MGC803 and BGC823) |
| Expression Pattern | down-regulated |
| Function Description | PTENP1 and PTEN were concurrently downregulated in GC samples. PTENP1 overexpression inhibited cell growth and induced apoptosis in GC cells. We further demonstrated that PTENP1 could act as a ceRNA to sponge miR-106b and miR-93 from targeting PTEN for downregulation using a novel ceRNA in vitro gradient assay. |
| Pubmed ID | 28212532 |
| Year | 2017 |
| Title | Long non-coding RNA PTENP1 functions as a ceRNA to modulate PTEN level by decoying miR-106b and miR-93 in gastric cancer. |
External Links
| Links for PTENP1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |