Basic Information
| LncRNA/CircRNA Name | PTENP1 |
| Synonyms | PTENP1, PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN |
| Region | GRCh38_9:33673504-33677499 |
| Ensemble | ENSG00000237984 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR |
| Sample | breast cancer tissues, cell line (MCF10A, MCF-7 and MDA-MB231) |
| Expression Pattern | down-regulated |
| Function Description | The expression of PTENP1 was significantly downregulated in both BC tissues and cell lines.Overexpressed PTENP1 could significantly increase the abilities of cell survival,colony forming, migration and invasion but decrease apoptosis in BC cell lines.PTENP1 performed a negative role in the development of BC via downregulating miR-19 through PTEN-PI3K/Akt pathway. |
| Pubmed ID | 29212574 |
| Year | 2017 |
| Title | Over-expression of long non-coding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells. |
External Links
| Links for PTENP1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |