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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	multiple myeloma
ICD-0-3	C42.1
Methods	qPCR, Western blot, Luciferase reporter assay
Sample	OPM2 and KMS-11 cells, blood
Expression Pattern	up-regulated
Function Description	Higher levels of PTENP1 and TSC1 mesenger RNA (mRNA) were observed in the MM group, along with a lower level of miR-19b. Moreover, the protein level of TSC1 in the MM group was evidently upregulated compared to that in the negative control (NC) group. Meanwhile, compared to the CG and GG groups, the CC group showed higher levels of PTENP1 and TSC1 mRNA, as well as a lower level of miR-19b. According to the results of real-time PCR, a negative correlation with a correlation coefficient of ??.05 was established between PTENP1 and miR-19b expression. Similarly, a negative correlation with a correlation coefficient of ??.05 was also established between miR-19b and TSC1 expression. In addition, the transfection of pcDNA-PTENP1 or anti-miR-19b into cells significantly suppressed miR-19b expression but obviously increased TSC1 expression. The G allele of rs7853346 polymorphism enhances the proliferation of MM cancer stem cells by promoting the expression of PTENP1 as well as its downstream signaling molecules.
Pubmed ID	31338886
Year	2019
Title	G allele of rs7853346 polymorphism in PTENP1 enhances the proliferation of multiple myeloma cancer stem cells by promoting the expression of PTENP1 and its downstream signaling molecules

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