Basic Information
| LncRNA/CircRNA Name | PTENP1 |
| Synonyms | PTENP1, PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN |
| Region | GRCh38_9:33673504-33677499 |
| Ensemble | ENSG00000237984 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, other |
| Sample | Bladder cancer tissues and cell lines (EJ and J82), Exosome |
| Expression Pattern | down-regulated |
| Function Description | We found that PTENP1 was mainly wrapped by exosomes. Exosomal PTENP1 could distinguish patients with BC from healthy controls. Normal cells secreted exosomal PTENP1 and transmitted it to BC cells, thus inhibiting the biological malignant behavior of BC cells by increasing cell apoptosis and reducing the ability to invade and migrate . Exosomal PTENP1 could suppress tumor growth in vivo. Furthermore, exosomal PTENP1 mediated the expression of PTEN by competitively binding to microRNA-17. |
| Pubmed ID | 30285771 |
| Year | 2018 |
| Title | Exosome-transmitted Long Non-Coding RNA PTENP1 Suppresses Bladder Cancer Progression |
External Links
| Links for PTENP1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |