Basic Information
| LncRNA/CircRNA Name | PTENP1 |
| Synonyms | PTENP1, PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN |
| Region | GRCh38_9:33673504-33677499 |
| Ensemble | ENSG00000237984 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay etc |
| Sample | glioma tissues, cell line (U87) |
| Expression Pattern | differential expressed |
| Function Description | Mechanistically, we identified that lncRNA PTENP1 could be packaged into exosome from hUC-MSCs, transferred to U87 cells, and then stabilized PTEN by binding miR-10a-5p competitively. |
| Pubmed ID | 31799671 |
| Year | 2020 |
| Title | hUC-MSCs Secreted Exosomes Inhibit the Glioma Cell Progression Through PTENP1/miR-10a-5p/PTEN Pathway |
External Links
| Links for PTENP1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |