Basic Information
| LncRNA/CircRNA Name | PTCSC3 |
| Synonyms | NA |
| Region | GRCh38_14:36136108-36176468 |
| Ensemble | ENSG00000259104 |
| Refseq | NR_049735 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | thyroid cancer tissues, cell line (TPC-1) |
| Expression Pattern | up-regulated |
| Function Description | Expression data from PTC cell lines pinpointed S100A4 as the most significantly downregulated gene in the presence of PTCSC3. S100A4 was upregulated in tumor tissue while PTCSC3 was strongly downregulated. S100A4 transcription was moderately correlated with PTCSC3 expression in unaffected thyroid tissue, and strongly in unaffected tissue of patients with the risk allele of rs944289. S100A4, VEGF and MMP-9 were suppressed in the presence of PTCSC3. PTC cells expressing PTCSC3 showed reduction in motility and invasiveness. |
| Pubmed ID | 26274343 |
| Year | 2015 |
| Title | PTCSC3 is involved in papillary thyroid carcinoma development by modulating S100A4 gene expression. |
External Links
| Links for PTCSC3 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |