Basic Information
| LncRNA/CircRNA Name | PTCSC3 |
| Synonyms | NA |
| Region | GRCh38_14:36136108-36176468 |
| Ensemble | ENSG00000259104 |
| Refseq | NR_049735 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | papillary thyroid carcinoma tissues, cell lines (PTC-1, Nthy-ori3-1) |
| Expression Pattern | down-regulated |
| Function Description | The expression of PTCSC3 and SCAI were decreased, while miR-574-5p and B-catenin were increased in PTC tissues and cells. Overexpressed PTCSC3 suppressed cell proliferation and migration, promoted the expression of SCAI, but inhibited B-catenin. PTCSC3 absorbed miR-574-5p, and miR-574-5p targeted to SCAI; SCAI could regulate the activity of Wnt/B-catenin. PTCSC3/miR-574-5p regulated the activity of Wnt/B-catenin via SCAI and mediated cell proliferation and migration of PTC-1.overexpressed PTCSC3 inhibited tumor growth. The signaling PTCSC3-miR-574-5p-SCAI-Wnt/B-catenin mediated the proliferation and migration of PTC-1 cells, which was vital for the further PTC therapy and prognosis. |
| Pubmed ID | 28513866 |
| Year | 2017 |
| Title | LncRNA PTCSC3/miR-574-5p Governs Cell Proliferation and Migration of Papillary Thyroid Carcinoma via Wnt/B-Catenin Signaling. |
External Links
| Links for PTCSC3 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |