Basic Information
| LncRNA/CircRNA Name | PTCSC3 |
| Synonyms | NA |
| Region | GRCh38_14:36136108-36176468 |
| Ensemble | ENSG00000259104 |
| Refseq | NR_049735 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, CCK-8 assay etc. |
| Sample | cell lines (U87, U251, SHG44 & SHG139) |
| Expression Pattern | down-regulated |
| Function Description | PTCSC3 was significantly downregulated in glioma cell lines. The overexpression of lncRNA PTCSC3 suppressed proliferation and induced apoptosis in U87 and U251 cells. Additionally, the overexpression of lncRNA PTCSC3 inhibited the migration and invasion of U87 and U251 cells. Moreover, lncRNA PTCSC3 inhibited the epithelial-mesenchymal transition of U87 cells. The study also demonstrated that lncRNA PTCSC3 inhibited the activation of the Wnt/B-cateninpathway through targeting LRP6. |
| Pubmed ID | 28187755 |
| Year | 2017 |
| Title | Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/B-catenin signaling pathway. |
External Links
| Links for PTCSC3 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |