Basic Information
| LncRNA/CircRNA Name | PTCSC2 |
| Synonyms | NA |
| Region | GRCh38_9:97805935-97810008 |
| Ensemble | ENSG00000236130 |
| Refseq | NR_147055 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | RIP, Dual luciferase reporter assay, RNA pull-down assay etc. |
| Sample | thyroid cancer tissues, cell lines (KTC1, BCPAP, C643, SW1736, TPC1, FTC133) |
| Expression Pattern | differential expression |
| Function Description | Here we report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activity in both directions. This inhibition can be reversed by PTCSC2, which acts as a suppressor. RNA knockdown of FOXE1 in primary thyroid cells profoundly interferes with the p53 pathway. We propose that the interaction between the lncRNA, its binding protein MYH9, and the coding gene FOXE1 underlies the predisposition to PTC triggered by rs965513. |
| Pubmed ID | 28049826 |
| Year | 2017 |
| Title | MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus. |
External Links
| Links for PTCSC2 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |