Basic Information
| LncRNA/CircRNA Name | PTAR |
| Synonyms | AP000695.4 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | NSCLC tissues, lung adenocarcinoma cell line A549, human lung squamous carcinoma cell line 95D and human normal lung epithelial cell line DEA S-2B |
| Expression Pattern | up-regulated |
| Function Description | in human NSCLC tissues and cell lines, lncRNA PTAR expression was upregulated compared with normal lung tissues and cell lines, respectively. Additionally, PTAR transfection was observed to promote A549 cell proliferation, migration and invasion; opposing effects were observed with siRNA PTAR transfection. The luciferase activity assay revealed that PTAR could act as a sponge to bind miR 101. Thus, miR 101 plays a role in NSCLC tumorigenesis and progression. In conclusion, lncRNA PTAR was proposed to promote NSCLC cell growth through sponging and inactivating miR 101, which may be a possible mechanism underlying miR 101 copy loss in human NSCLC. |
| Pubmed ID | 31485653 |
| Year | 2019 |
| Title | lncRNA PTAR promotes NSCLC cell proliferation, migration and invasion by sponging microRNA-101 |
External Links
| Links for PTAR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |