Basic Information
| LncRNA/CircRNA Name | PTAF |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | ovarian cancer tissues, cell lines(SKOV3, A2780 and OVCAR-3) |
| Expression Pattern | up-regulated |
| Function Description | The lncRNA PTAF was significantly up-regulated in mesenchymal OvCa compared with epithelial OvCa. High PTAF expression showed a poorer prognosis than those with low PTAF expression (P????.043). Up-regulated PTAF induced elevated SNAI2 expression by competitively binding to miR-25, which in turn promoted OvCa cell EMT and invasion. Moreover, we found that silencing of PTAF inhibited tumor progression and metastasis in an orthotopic mouse model of OvCa. We then observed a significant correlation between PTAF expression and EMT markers in OvCa patients. |
| Pubmed ID | 29929545 |
| Year | 2018 |
| Title | Systematic Analyses Reveal Long Non-Coding RNA (PTAF)-mediated Promotion of EMT and Invasion-Metastasis in Serous Ovarian Cancer |
External Links
| Links for PTAF | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |