Basic Information
| LncRNA/CircRNA Name | PRRG4-4 |
| Synonyms | PRGP4, TMG4 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, other |
| Sample | lung cancer tissues and cell lines (i.e., Glc-82, NCI-H520, L78, A549,PC9, NCI-H460, and NCI-H292) |
| Expression Pattern | up-regulated |
| Function Description | Patients with metastasis exhibited high levels of lncPRRG4-4 expression than those without metastasis in both the southern samples (p = 0.045) and eastern samples (p = 0.030), total samples (p = 0.004). In addition, downregulation of lncPRRG4-4 expression inhibited lung cancer proliferation, viability, migration, and invasion ability, arrested cell cycle, facilitated apoptosis, and vice versa. Taken together, these observations suggested that the lncPRRG4-4 functions as an oncogene in lung cancer cells. |
| Pubmed ID | 30362823 |
| Year | 2018 |
| Title | Long Noncoding RNA PRRG4-4 Promotes Viability, Cell Cycle, Migration, and Invasion in Lung Cancer Cells |
External Links
| Links for PRRG4-4 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |