Basic Information
| LncRNA/CircRNA Name | PROX1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:214028891-214030901 |
| Ensemble | ENSG00000230461 |
| Refseq | NR_037850 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | cell lines (KTC1, TPC1, BCPAP) |
| Expression Pattern | up-regulated |
| Function Description | we found that PROX1-AS1 levels were obviously increased in thyroid cancer cells compared with the normal thyroid epithelial cells. Knockdown of PROX1-AS1 gene expression by siRNA could inhibit cell proliferation. we also observed that silencing PROX1-AS1 might inhibit invasion and migration of thyroid cancer cell lines via modulating the expression of epithelial-mesenchymal transition related proteins. |
| Pubmed ID | 30061172 |
| Year | 2018 |
| Title | LncRNA PROX1-AS1 Promotes Proliferation, Invasion, and Migration in Papillary Thyroid Carcinoma. |
External Links
| Links for PROX1-AS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |