Basic Information
| LncRNA/CircRNA Name | PRLH1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi, RIP, etc. |
| Sample | HCC tissues, cell lines (HepG2, PLC/PRF/5 ,SMMC-7721, 293T, LO2, HuH-7, and SK-HEP-1) |
| Expression Pattern | up-regulated |
| Function Description | Here, we report the function and regulatory mechanism of an ERV9 LTR retrotransposon-derived lncRNA called p53-regulated lncRNA for homologous recombination (HR) repair 1 (PRLH1) in human cells. PRLH1 is highly expressed in p53-mutated hepatocellular carcinoma (HCC) samples and promotes cell proliferation in p53- mutated HCC cells, and its transcription is promoted by NF-Y and suppressed by p53. Mechanistically, PRLH1 specifically binds to an uncharacterized domain of RNF169 through two GCUUCA boxes in its 50 terminal region to form a DNA repair complex that supplants 53BP1 at double-strand break (DSB) sites and then promotes the initiation of HR repair. Notably, PRLH1 is essential for the stabilization of RNF169, acting as an RNA platform to recruit and assemble HR protein factors. This study characterizes PRLH1 as a novel HRpromoting factor and provides new insights into the function and mechanism of LTR retrotransposon-derived lncRNAs |
| Pubmed ID | 31486214 |
| Year | 2019 |
| Title | An LTR retrotransposon-derived lncRNA interacts with RNF169 to promote homologous recombination |
External Links
| Links for PRLH1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |