Basic Information
| LncRNA/CircRNA Name | lncRNA-PRAL |
| Synonyms | PRAL, lncRNA-PRAL |
| Region | GRCh38_17:6772831-6776116 |
| Ensemble | ENSG00000279296 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | 5-FU | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR etc. |
| Sample | cell lines (SNU-C4R, SNU-C5R etc.) |
| Expression Pattern | down-regulated |
| Function Description | We selected three lncRNAs, snaR, BACE1AS, and PRAS, and we detected their expression by RT-qPCR using specific primer sets. SnaR and BACE1AS were significantly down-regulated in both resistant cell lines (SNU-C4R and SNU-C5R), whereas PRAS was down-regulated in SNU-C4R cells but not in SNU-C5R cells. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. |
| Pubmed ID | 25078450 |
| Year | 2014 |
| Title | A long non-coding RNA snaR contributes to 5-fluorouracil resistance in human colon cancer cells. |
External Links
| Links for lncRNA-PRAL | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |