Basic Information
| LncRNA/CircRNA Name | PlncRNA-1 |
| Synonyms | CBR3-AS1, PlncRNA-1, PlncRNA1 |
| Region | GRCh38_21:36131767-36175815 |
| Ensemble | ENSG00000236830 |
| Refseq | NR_038892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | CRC tissues, cell lines (SW480, DLD-1, HCT116, SW620, HcoEpiC) |
| Expression Pattern | up-regulated |
| Function Description | High PlncRNA-1 expression was associated with depth of invasion, lymph node metastasis, and TNM stage of CRC patients. Kaplan-Meier curve analysis showed that patients with high PlncRNA-1 expression had a poor overall survival.PlncRNA-1 exerted its effects by targeting the PI3K/Akt signaling pathway in CRC. |
| Pubmed ID | 28835319 |
| Year | 2017 |
| Title | Long Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell Progression by Regulating the PI3K/Akt Signaling Pathway. |
External Links
| Links for PlncRNA-1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |