Basic Information
LncRNA/CircRNA Name | PlncRNA-1 |
Synonyms | CBR3-AS1, PlncRNA-1, PlncRNA1 |
Region | GRCh38_21:36131767-36175815 |
Ensemble | ENSG00000236830 |
Refseq | NR_038892 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | breast cancer |
ICD-0-3 | C50 |
Methods | qPCR, Western blot etc. |
Sample | cell line (MCF-7,MDA-MB-468), breast cancer |
Expression Pattern | down-regulated |
Function Description | Expression levels of PlncRNA-1 were significantly lower in tumor tissues than those in adjacent healthy tissues. Significantly lower expression levels of PlncRNA-1 were also found in breast cancer patients than those in healthy controls in both breast tissue and serum. Upregulation of PlncRNA-1 promoted the expression of TGF-B1, but inhibited the expression of PHGDH. LncRNA PlncRNA-1 overexpression reduced the proliferation rate, but increased the apoptosis rate of breast cancer cells, while treatment with TGF-B inhibitor reduced those effects of PlncRNA-1 overexpression. |
Pubmed ID | 29626321 |
Year | 2018 |
Title | LncRNA PlncRNA-1 overexpression inhibits the growth of breast cancer by upregulating TGF-B1 and downregulating PHGDH. |
External Links
Links for PlncRNA-1 | GenBank HGNC NONCODE |
Links for breast cancer | OMIM COSMIC |