Basic Information
| LncRNA/CircRNA Name | PlncRNA-1 |
| Synonyms | NA |
| Region | GRCh38_21:36131767-36175815 |
| Ensemble | ENSG00000236830 |
| Refseq | NR_038892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, Western blot |
| Sample | retinoblastoma tissue, cell lines (Weri-Rb1, Y79, ARPE-19, HRMECs) |
| Expression Pattern | up-regulated |
| Function Description | The results showed the level of PlncRNA-1 expression was obviously increased in retinoblastoma tissues and cell lines compared with compared with normal retina tissues and retina cell lines, respectively. The in vitro experiments showed that down-regulation of PlncRNA-1 expression suppressed retinoblastoma cell proliferation, migration and invasion through up-regulating CBR3. |
| Pubmed ID | 30096220 |
| Year | 2018 |
| Title | PlncRNA-1 Is Overexpressed in Retinoblastoma and Regulates Retinoblastoma Cell Proliferation and Motility Through Modulating CBR3. |
External Links
| Links for PlncRNA-1 | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |