Basic Information
| LncRNA/CircRNA Name | PLACT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR, Western blot |
| Sample | PDAC tissues,cell lines (AsPC-1, BxPC-3, Capan-2, CFPAC-1, MIA PaCa-2, PANC-1 and SW1990) |
| Expression Pattern | up-regulated |
| Function Description | administration of the NF-?B signaling pathway inhibitor significantly suppressed PLACT1-induced sustained activation of NF-?B signaling pathway, leading to reduced tumorigenesis in vivo. |
| Pubmed ID | 32085715 |
| Year | 2020 |
| Title | lncRNA-PLACT1 sustains activation of NF-?B pathway through a positive feedback loop with I?B?/E2F1 axis in pancreatic cancer |
External Links
| Links for PLACT1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |