Basic Information
| LncRNA/CircRNA Name | PICSAR |
| Synonyms | ?C21orf113, LINC00162, NCRNA00162, NLC1-C, NLC1C, PRED74 |
| Region | GRCh38_21:44999208-45004727 |
| Ensemble | ENSG00000275874 |
| Refseq | NR_024089 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cutaneous squamous cell carcinoma |
| ICD-0-3 | C49 |
| Methods | RNA-seq, qPCR, Western blot, other |
| Sample | Cutaneous SCC cell lines (UT-SCC12A and UT-SCC59) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of PICSAR in cSCC cells upregulates expression of ?2, ?5 and ?1 integrins, resulting in increased cell adhesion and decreased cell migration on collagen I and fibronectin. In contrast, overexpression of PICSAR in cSCC cells downregulates expression of ?2, ?5 and ?1 integrins on cell surface, resulting in decreased cell adhesion on collagen I and fibronectin and increased cell migration. These results demonstrate a novel mechanism for regulation of the expression of collagen and fibronectin binding integrins by lncRNA PICSAR, leading to altered adhesion and migration of cSCC cells. |
| Pubmed ID | 30429154 |
| Year | 2018 |
| Title | Long Non-Coding RNA PICSAR Decreases Adhesion and Promotes Migration of Squamous Carcinoma Cells by Downregulating ?2?1 and ?5?1 Integrin Expression |
External Links
| Links for PICSAR | GenBank HGNC NONCODE |
| Links for cutaneous squamous cell carcinoma | OMIM COSMIC |