Basic Information
| LncRNA/CircRNA Name | BCAR4 |
| Synonyms | NA |
| Region | GRCh38_16:11819829-11828845 |
| Ensemble | ENSG00000262117 |
| Refseq | NR_024049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (BEAS-2B, A549), NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA BCAR4 in NSCLC tissues and cells was significantly higher than normal level. The overexpression of BCAR4 promoted NSCLC cell viability, migration, and invasion. The suppression of BCAR4 and GLI2 showed the opposite effects. The overexpression of BCAR4 led to the increase in the expression of GLI2 downstream proteins, while the suppression of BCAR4 and GLI2 reduced their expression. In tumor xenograft assay, tumors in mice of BCAR4 group showed the biggest volume, while those in mice of si-GLI2 group showed the smallest volume. Ki67 showed much higher level in BCAR4 overexpression group but much lower level in si-GLI2 group. |
| Pubmed ID | 29615150 |
| Year | 2018 |
| Title | LncRNA BCAR4 increases viability, invasion and migration non-small cell lung cancer cells by targeting glioma-associated oncogene 2(GLI2) |
External Links
| Links for BCAR4 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |