Basic Information
| LncRNA/CircRNA Name | PICART1 |
| Synonyms | RP11-1094H24.4, PICART1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Cell transfection, Western blot, Cell proliferation assay etc. |
| Sample | breast cancer tissues, cell lines (MCF7, MDA-MB-231) |
| Expression Pattern | down-regulated |
| Function Description | In breast and colorectal cancer cells and tissues, PICART1 expression was found to be decreased. Ectopic expression of PICART1 suppressed the growth, proliferation, migration, and invasion of MCF7, MDA-MB-231 and HCT116 cells whereas silencing of PICART1 stimulated cell growth and migration. In these cells, the expression of PICART1 suppressed levels of p-AKT (Thr308 and Ser473) and p-GSK3B (Ser9), and accordingly, B-catenin, cyclin D1 and c-Myc expression were decreased, while p21Waf/cip1 expression was increased. |
| Pubmed ID | 28339031 |
| Year | 2017 |
| Title | p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. |
External Links
| Links for PICART1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |