Basic Information
| LncRNA/CircRNA Name | PGM5-AS1 |
| Synonyms | NA |
| Region | GRCh38_9:68355189-68357852 |
| Ensemble | ENSG00000224958 |
| Refseq | NR_015423 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | ESCC and adjacent normal tissues,The human normal esophageal epithelial cell line HET-1A,ESCC cell lines (EC109, KYSE150, KYSE450, KYSE30, TE-1, TE-10), ESCC plasma samples |
| Expression Pattern | down-regulated |
| Function Description | PGM5-AS1 was frequently downregulated in ESCC tissues, plasma, and cell lines, and low PGM5-AS1 expression was positively correlated with poor differentiation, advanced tumor node metastasis (TNM) stage, and lymph node metastasis.Importantly, PGM5-AS1 was identified to be an effective diagnostic and prognostic biomarker for ESCC patients. Functional experiments revealed that exogenous expression of PGM5-AS1 significantly suppressed the proliferation, migration, and invasion of ESCC cells in vitro as well as tumor growth in vivo. Mechanistically, PGM5-AS1 was transcriptionally activated by p53 and it could directly interact with and sequester miR-466 to elevate PTEN expression, thereby inhibiting ESCC progression. |
| Pubmed ID | 31185143 |
| Year | 2019 |
| Title | p53-induced Long Non-Coding RNA PGM5-AS1 Inhibits the Progression of Esophageal Squamous Cell Carcinoma Through Regulating miR-466/PTEN Axis |
External Links
| Links for PGM5-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |