Basic Information
| LncRNA/CircRNA Name | PEG10 |
| Synonyms | PEG10, EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3, RTL2, SIRH1 |
| Region | GRCh38_7:94656325-94669695 |
| Ensemble | ENSG00000242265 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Flow cytometry, etc. |
| Sample | gastric cancer tissues, cell line (NCI-N87) |
| Expression Pattern | up-regulated |
| Function Description | PEG10 knockdown effectively inhibited gastric carcinoma cell viability, migration, and invasion, but promoted cell apoptosis.AEG1 was a direct target gene of miR-3200. PEG10 knockdown played a carcinostatic role via up-regulating miR-3200 and further regulating AEG1 in gastric carcinoma cells, during which process, JNK pathway and Wnt pathway were blocked. |
| Pubmed ID | 29940767 |
| Year | 2018 |
| Title | Knockdown of long non-coding RNA PEG10 inhibits growth, migration and invasion of gastric carcinoma cells via up-regulating miR-3200. |
External Links
| Links for PEG10 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |