Basic Information
| LncRNA/CircRNA Name | PEG10 |
| Synonyms | PEG10, EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3, RTL2, SIRH1 |
| Region | GRCh38_7:94656325-94669695 |
| Ensemble | ENSG00000242265 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hypopharyngeal squamous cell carcinoma |
| ICD-0-3 | C13 |
| Methods | qPCR |
| Sample | tumor tissue and para-carcinoma tissue, HSCC FaDu cell line. |
| Expression Pattern | up-regulated |
| Function Description | In the in vitro experimental studies, enhanced expression of lncRNA PEG10 was significantly associated with increased proliferation, invasion and metastasis of FaDu cells. lncRNA PEG10 was upregulated in HSCC, and its overexpression in HSCC cells promoted an increase in the tumorigenic activities of proliferation, invasion and migration.A total of >75% of patients with HSCC have an advanced stage of the disease at the time of diagnosis (2), and the prognosis of these patients is poor with a 5-year overall survival rate of 30-35% (3-5). |
| Pubmed ID | 28928830 |
| Year | 2017 |
| Title | Overexpression of long noncoding RNA PEG10 promotes proliferation, invasion and metastasis of hypopharyngeal squamous cell carcinoma. |
External Links
| Links for PEG10 | GenBank HGNC NONCODE |
| Links for hypopharyngeal squamous cell carcinoma | OMIM COSMIC |