Basic Information
| LncRNA/CircRNA Name | PDIA3P |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blotting etc. |
| Sample | NSCLC tissues and the adjacent normal tissues, The human NSCLC cell lines(A549, H1299, H1703, H520 and SK-MES-1), normal human bronchial epithelium cell line BEAS-2B |
| Expression Pattern | up-regulated |
| Function Description | LncRNA PDIAP3 expression was significantly increased in patients with NSCLC, particularly in patients with an advanced Tumor-Node-Metastasis stages and lymph-node metastasis. The Gene Expression Profiling Interactive Analysis database revealed that patients with NSCLC with high lncRNA PDIA3P expression had a poorer disease-free survival rate. Furthermore, functional assays suggested that PDIA3P inhibition significantly suppressed the proliferation and invasion of NSCLC cells in vitro and reduced tumor growth in vivo. In addition, lncRNA PDIA3P enhanced the activity of the Wnt/?-catenin pathway in progression of NSCLC. |
| Pubmed ID | 31572559 |
| Year | 2019 |
| Title | lncRNA PDIA3P Regulates Cell Proliferation and Invasion in Non-Small Cell Lung Cancer |
External Links
| Links for PDIA3P | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |