Basic Information
| LncRNA/CircRNA Name | PDIA3P |
| Synonyms | protein disulfide isomerase family A member 3 pseudogene 1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay |
| Sample | Tumor tissues,BC cell lines MCF-7 and MDA-MB-231 as well as normal human mammary epithelial cell line MCF10A |
| Expression Pattern | up-regulated |
| Function Description | PDIA3P was discovered as up-regulated in BC tissues and cells. PDIA3P suppression markedly decreased cell viability, promoted apoptosis, and inhibited migration and invasion in MCF-7 cells.PDIA3P was found to be negatively interacting with miR-183, and PDIA3P regulated tumor growth and metastasis through negatively regulating miR-183. |
| Pubmed ID | 31933942 |
| Year | 2019 |
| Title | Long Noncoding RNA PDIA3P Promotes Breast Cancer Development by Regulating miR-183/ITGB1/FAK/PI3K/AKT/?-catenin Signals |
External Links
| Links for PDIA3P | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |