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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	pancreatic cancer
ICD-0-3	C25
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown
Sample	pancreatic cancer tissues, cell lines (PANC-1, MiaPaCa-2, BxPC-3 and AsPC-1)
Expression Pattern	down-regulated
Function Description	lnc-PCTST expression is down-regulated in PC tissues. Also, lnc-PCTST has shown to be negatively correlated with transforming acidic coiled-coil 3 (TACC-3) expression. This expression pattern was further confirmed following qRT-PCR validation of 34 out of 48 paired cancer tissues. Furthermore, lnc-PCTST overexpression in PC cell lines inhibited cell proliferation and invasion in vitro, but did not altered cell migration. Moreover, lnc-PCTST overexpression increased E-cadherin and repressed vimentin expression in vitro. Additionally, TACC-3 knockdown simulated the inhibiting effect of lnc-PCTST overexpression on PC cell lines, and the impaired proliferation, invasion effect and E-cadherin, vimentin expression on lnc-PCTST over-expressed cell lines can be rescued by overexpressed TACC-3. Overall survival analysis revealed that high lnc-PCTST expression was significantly correlated with longer overall survival (log-rank test, p < 0.001). Significantly, the expression of lnc-PCTST was closely associated with its genomic neighboring gene TACC-3 and inhibited its promoter activity. In conclusion, lnc-PCTST is a potential tumor suppressor in PC, which inhibits cell proliferation, invasion, tumorigenesis and EMT by modulating TACC-3.
Pubmed ID	29978472
Year	2018
Title	Long Non-Coding RNA lnc-PCTST Predicts Prognosis Through Inhibiting Progression of Pancreatic Cancer by Downregulation of TACC-3

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