Basic Information
| LncRNA/CircRNA Name | PCOTH |
| Synonyms | PCOTH, C1QTNF9B-AS1 |
| Region | GRCh38_13:23888889-23897263 |
| Ensemble | ENSG00000205861 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Northern blot etc. |
| Sample | prostate cancer tissues, cell lines (LNCaP, DU145, PC-3CaP etc.) |
| Expression Pattern | up-regulated |
| Function Description | We identified a novel gene, prostate collagen triple helix (PCOTH), showing overexpression in prostate cancer cells and its precursor cells, prostatic intraepithelial neoplasia (PIN). Knocking down PCOTH expression by small interfering RNA (siRNA) resulted in drastic attenuation of prostate cancer cell growth, and concordantly, LNCaP derivative cells that were designed to constitutively express exogenous PCOTH showed higher growth rate than LNCaP cells transfected with mock vector, suggesting the growth-promoting effect of PCOTH on prostate cancer cell. |
| Pubmed ID | 15930275 |
| Year | 2005 |
| Title | PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. |
External Links
| Links for PCOTH | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |