Basic Information
| LncRNA/CircRNA Name | PCGEM1 |
| Synonyms | PCGEM1, LINC00071, NCRNA00071, PCAT9 |
| Region | GRCh38_2:192749845-192776899 |
| Ensemble | ENSG00000227418 |
| Refseq | NR_002769 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, etc. |
| Sample | ovarian cancer tissues, cell lines (A2780, OVCAR3) |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of PCGEM1 induced cancer cell proliferation, migration, and invasion, but decreased cell apoptosis through upregulating RhoA, YAP (Yes-associated protein), MMP2 (matrix metalloproteinase 2), Bcl-xL, and P70S6K expression; |
| Pubmed ID | 29949791 |
| Year | 2018 |
| Title | LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway. |
External Links
| Links for PCGEM1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |