Basic Information
| LncRNA/CircRNA Name | PCGEM1 |
| Synonyms | PCGEM1, LINC00071, NCRNA00071, PCAT9 |
| Region | GRCh38_2:192749845-192776899 |
| Ensemble | ENSG00000227418 |
| Refseq | NR_002769 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | doxorubicin (DOX) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | Northern blot etc. |
| Sample | cell line (LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | This data suggests that overexpression of PCGEM1 attenuated the induction of apoptosis in LNCaP cells. This study provides new insights into cell biologic functions and novel features of an ncRNA. Further, these data unravel biological mechanisms of cell growth/cell survival-associated functions of this ncRNA in a widely used prostate cancer cell culture model. |
| Pubmed ID | 16569192 |
| Year | 2006 |
| Title | Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. |
External Links
| Links for PCGEM1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |