Basic Information
| LncRNA/CircRNA Name | PCAT7 |
| Synonyms | prostate cancer-associated transcript 7 |
| Region | GRCh38_9:94555054-94603990 |
| Ensemble | ENSG00000231806 |
| Refseq | NR_121566 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR, Western blotting, Luciferase reporter assay, RIP |
| Sample | PCa cell lines (LNCaP, PC-3, 22RV1, VCaP, DU145) and normal prostate epithelial cells (RWPE-1),PCa tissues |
| Expression Pattern | up-regulated |
| Function Description | PCAT7 was found to be elevated in primary PCa tissues with bone metastasis and associated with bone metastasis status and poor prognosis of patients with PCa.PCAT7 overexpression promotes PCa bone metastasis in vivo, as well as migration, invasion, and EMT of PCa cells in vitro; on the contrary, PCAT7 knockdown has an inverse effect. Mechanistically, PCAT7 activates TGF-?/SMAD signaling by upregulating TGFBR1 expression via sponging miR-324-5p. In turn, TGF-? signaling forms a positive feedback loop with PCAT7 via SMAD3/SP1 complex-induced PCAT7 upregulation. |
| Pubmed ID | 31925912 |
| Year | 2020 |
| Title | SMAD3/SP1 Complex-Mediated Constitutive Active Loop Between lncRNA PCAT7 and TGF-? Signaling Promotes Prostate Cancer Bone Metastasis |
External Links
| Links for PCAT7 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |