Basic Information
| LncRNA/CircRNA Name | PCAT6 |
| Synonyms | PCAT6, KDM5B-AS1, KDM5BAS1, PCAN-R1, ncRNA-a2, onco-lncRNA-96 |
| Region | GRCh38_1:202810954-202812156 |
| Ensemble | ENSG00000228288 |
| Refseq | NR_046325 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay, other |
| Sample | NSCLC cell lines and tissuess (H1650, HCC827, A549, and H1975), non-tumorigenic bronchial epithelial cell line (BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | PCAT6 was highly overexpressed in NSCLC tissues and cells compared with normal tissues and non-tumorigenic bronchial epithelial cell line, BEAS-2B. Downregulation of PCAT6 markedly reduced the proliferation, migration, and invasion of NSCLC cell. Moreover, down-expression of PCAT6 significantly increased the level of miR-330-5p in NSCLC cell. Further functional experiments indicated that down-expression of miR-330-5p reversed the inhibitory effect of PCAT6 on NSCLC cell growth, migration, and invasion.lncRNA PCAT6 facilitates the proliferation, migration, and invasion of NSCLC cell via competitively binding to miR-330-5p. |
| Pubmed ID | 30464520 |
| Year | 2018 |
| Title | lncRNA PCAT6 Promotes Non-Small Cell Lung Cancer Cell Proliferation, Migration and Invasion Through Regulating miR-330-5p |
External Links
| Links for PCAT6 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |