Basic Information
| LncRNA/CircRNA Name | PCAT6 |
| Synonyms | NA |
| Region | GRCh38_1:202810954-202812156 |
| Ensemble | ENSG00000228288 |
| Refseq | NR_046325 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blotting, Luciferase reporter assays |
| Sample | OS tissues,OS cell lines |
| Expression Pattern | up-regulated |
| Function Description | PCAT6 was elevated in OS tissues relative to that in their adjacent normal tissues. The upregulation of PCAT6 was positively associated with metastasis status and advanced stages and predicted poor overall and progression-free survivals in patients with OS. Functionally, silencing PCAT6 inhibited the proliferation, migration and invasion abilities of OS cells. Mechanistically, PCAT6, acting as a competitive endogenous RNA, upregulated expression of TGFBR1 and TGFBR2 to activate TGF-? pathway via sponging miR-185-5p. |
| Pubmed ID | 31676070 |
| Year | 2020 |
| Title | LncRNA PCAT6 Promotes Tumor Progression in Osteosarcoma via Activation of TGF-? Pathway by Sponging miR-185-5p |
External Links
| Links for PCAT6 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |