Basic Information
| LncRNA/CircRNA Name | PCAT6 |
| Synonyms | NA |
| Region | GRCh38_1:202810954-202812156 |
| Ensemble | ENSG00000228288 |
| Refseq | NR_046325 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastrointestinal stromal tumor |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc |
| Sample | GIST tissue samples, cell lines(GIST-H1, GIST-882, GIST-T1,GIST-48) |
| Expression Pattern | up-regulated |
| Function Description | PCAT6 could activate Wnt/?-catenin pathway. And the tumor facilitator role of Wnt/?-catenin pathway was validated in the rescue assays. Next, miR-143-3p was identified as the downstream microRNA of PCAT6. Moreover, miR-143-3p itself served as a tumor suppressor in GIST. Subsequently, peroxiredoxin 5 (PRDX5) was verified as the target of miR-143-3p. |
| Pubmed ID | 32339330 |
| Year | 2020 |
| Title | PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway. |
External Links
| Links for PCAT6 | GenBank HGNC NONCODE |
| Links for gastrointestinal stromal tumor | OMIM COSMIC |