Basic Information
| LncRNA/CircRNA Name | BCAR4 |
| Synonyms | NA |
| Region | GRCh38_16:11819829-11828845 |
| Ensemble | ENSG00000262117 |
| Refseq | NR_024049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | osteosarcoma tissues, cell lines (hFOB 1.19, MG63 and U2-OS) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we found that BCAR4 was significantly upregulated in osteosarcoma tissues. Increased expression of BCAR4 was significantly correlated with large tumor size, advanced Enneking stage, lung metastasis, and poor prognosis. Functional experiments demonstrated that knockdown of BCAR4 inhibits the proliferation and migration of osteosarcoma cell in vitro. Consistently, knockdown of BCAR4 inhibits osteosarcoma tumorigenesis and lung metastasis in vivo. |
| Pubmed ID | 27460090 |
| Year | 2016 |
| Title | Long noncoding RNA BCAR4 promotes osteosarcoma progression through activating GLI2-dependent gene transcription. |
External Links
| Links for BCAR4 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |