Basic Information
| LncRNA/CircRNA Name | PCAT18 |
| Synonyms | PCAT18, LINC01092 |
| Region | GRCh38_18:26687621-26703638 |
| Ensemble | ENSG00000265369 |
| Refseq | NR_024259 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | cell lines (LTL313B, LTL313H etc.) |
| Expression Pattern | up-regulated |
| Function Description | PCAT18 is specifically expressed in the prostate compared to 11 other normal tissues and up-regulated in PCa compared to 15 other neoplasms. Cancer-specific up-regulation of PCAT18 was confirmed on an independent dataset of PCa and benign prostatic hyperplasia samples. PCAT18 was detectable in plasma samples and increased incrementally from healthy individuals to those with localized and metastatic PCa. |
| Pubmed ID | 24519926 |
| Year | 2014 |
| Title | Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. |
External Links
| Links for PCAT18 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |