Basic Information
| LncRNA/CircRNA Name | PCAT18 |
| Synonyms | Prostate cancer-associated transcript 18 |
| Region | GRCh38_18:26687621-26703638 |
| Ensemble | ENSG00000265369 |
| Refseq | NR_024259 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot analysis, Dual Luciferase Reporter Assay |
| Sample | GC tissues,gastric epithelial cell line (GES-1, CBP60512) and human GC cell lines (AGS (CBP60476), MGC-803 (CBP60485), NCI-N87 (CBP60491), and HGC-27 (CBP60480)) |
| Expression Pattern | down-regulated |
| Function Description | PCAT18 was down-regulated in GC tissues and cells, and it had a significant diagnostic value for GC. The expression of PCAT18 was highly associated with tumor size, and PCAT18 was found to inhibit GC growth in vitro and in vivo. It was also found that PCAT18 was involved in PTEN/PI3K/AKT signaling pathway through targeting miR-107. |
| Pubmed ID | 31853187 |
| Year | 2019 |
| Title | The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway |
External Links
| Links for PCAT18 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |