Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RNA-seq, qPCR, Western blot etc. |
| Sample | prostate cancer tissues, cell lines (VCaP, LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | PCAT-1, which is markedly overexpressed in a subset of prostate cancers, particularly metastases that demonstrates either repression by PRC2 or an active role in promoting cell proliferation through transcriptional regulation of target genes. |
| Pubmed ID | 21804560 |
| Year | 2011 |
| Title | Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |