Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Cell migration assay, ELISA etc. |
| Sample | HCC tissues, cell lines (L02, HepG2 and Bel-7402) |
| Expression Pattern | up-regulated |
| Function Description | The results demonstrated that PCAT-1 was upregulated in HCC tissue samples and cell lines compared with adjacent non-cancerous tissues and the L02 normal liver epithelial cell line. PCAT-1 suppression using PCAT-1 small hairpin RNA in HepG2 and Bel-7402 cells inhibited cell proliferation and migration, and induced apoptosis. Overexpression of PCAT-1 induced synthetic plasmid vectors was demonstrated to increase cell proliferation and migration, and inhibit apoptosis. |
| Pubmed ID | 27035680 |
| Year | 2016 |
| Title | Upregulation of long non coding RNA PCAT-1 contributes to cell proliferation, migration and apoptosis in hepatocellular carcinoma. |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |