Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | GC tissues, cell lines (AGS, BGC-823, MKN-45, HGC-27, GES-1) |
| Expression Pattern | up-regulated |
| Function Description | PCAT-1 is up-regulated in GC samples and cell lines.PCAT-1 expression was elevated in GC tissues and cell lines, and PCAT-1 levels were highly positively correlated with invasion depth (p < 0.001), TNM stages (p < 0.001) and lymphatic metastasis (p = 0.003).PCAT-1 may have potential roles as a biomarker and/or a therapeutic target in gastric cancer.The association between PCAT-1 expression and clinicopathological factors,as well as survival rates, was analyzed. |
| Pubmed ID | 28742205 |
| Year | 2017 |
| Title | Up-regulation of long non-coding RNA PCAT-1 correlates with tumor progression and poor prognosis in gastric cancer. |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |