Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | OS tumor tissues, human OS cell lines (Saos-2, U2OS, MG-63 and 143B) |
| Expression Pattern | up-regulated |
| Function Description | PCAT-1 expression was also upregulated in OS tissues,PCAT-1 could interact with EZH2, thereby repressing p21 expression. Additionally, rescue experiments indicated that PCAT-1 functioned as an oncogene partly via suppressing p21 in OS cells. |
| Pubmed ID | 29291409 |
| Year | 2017 |
| Title | Long noncoding RNA PCAT-1 acts as an oncogene in osteosarcoma by reducing p21 levels. |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |