Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oesophageal cancer |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | oesophageal cancer tissues, cell lines (KYSE30, KYSE450, and Eca109) |
| Expression Pattern | up-regulated |
| Function Description | PCAT-1, showed higher expression in OC tissues, especially higher in secondary OC compared with normal mucosa tissues. Overexpression of PCAT-1 increased the proliferation rate and growth of OC cells. Inhibition of PCAT-1 decreased proliferation and growth of OC cells, and increased cisplatin chemosensitivity. PCAT-1 may potentially serve as a therapeutic target for treating OC.PCAT-1 promotes development of OC and represses the chemoresistance of OC to cisplatin, and silencing of PCAT-1 may be a therapeutic strategy for treating OC.the expression of HOTAIR in oesophageal squamous cell carcinoma was significantly higher than that in adjacent tissues, and it was significantly correlated with the metastasis, high stage, and survival rate of oesophageal carcinoma. |
| Pubmed ID | 29314203 |
| Year | 2017 |
| Title | LncRNA PCAT-1 promotes tumour growth and chemoresistance of oesophageal cancer to cisplatin. |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for oesophageal cancer | OMIM COSMIC |