Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-qPCR, Western blotting |
| Sample | EOC tissues,cell lines, including SKOV-3, OVCAR-3, HEY-A8, and HO8910-PM,IOSE-80 |
| Expression Pattern | up-regulated |
| Function Description | the expression of LncRNA PCAT-1 is up-regulated in EOC tissues compared with non-cancer controls by reverse transcription-quantitative polymerase chain reaction analysis (RT-qPCR), and its higher expression is always associated with larger tumor sizes and advanced tumor grades in patients with EOC. In addition, silencing PCAT-1 in the EOC cell lines SKOV3 and OVCAR3 significantly inhibits cell proliferation, migration and invasion, |
| Pubmed ID | 31934037 |
| Year | 2019 |
| Title | LncRNA PCAT-1 Plays an Oncogenic Role in Epithelial Ovarian Cancer by Modulating cyclinD1/CDK4 Expression |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |