Basic Information
| LncRNA/CircRNA Name | BCAR4 |
| Synonyms | breast cancer anti-estrogen receptor 4 |
| Region | GRCh38_16:11819829-11828845 |
| Ensemble | ENSG00000262117 |
| Refseq | NR_024049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | RT-qPCR, western blotting, Dual luciferase reporter assay |
| Sample | Tumor tissues,BC cell lines 5637, T24 and SW780 and human immortalized ureter epithelial cell line SV-HUC-1 |
| Expression Pattern | up-regulated |
| Function Description | elevated levels of lncRNA breast cancer anti-estrogen receptor 4 (BCAR4) were identified in BC tissues compared with matched healthy tissues. Silencing of BCAR4 inhibited cell proliferation and induced apoptosis in BC cell lines 5637 and T24. Downregulation of BCAR4 led to the inactivation of Wnt signaling. Mechanistically, BCAR4 directly sponged microRNA (miR)-370-3p and elevated Wnt7a expression. |
| Pubmed ID | 31894304 |
| Year | 2020 |
| Title | lncRNA BCAR4 Sponges miR-370-3p to Promote Bladder Cancer Progression via Wnt Signaling |
External Links
| Links for BCAR4 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |