Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | PCR |
| Sample | lung adenocarcinoma tissues |
| Expression Pattern | down-regulated |
| Function Description | A SNP located in a distal enhancer of lncRNA PCAT1 (prostate cancer associated transcript 1) alters the binding of its transcription factors ONECUT2 (one cut homeobox 2) and androgen receptor (AR) to the enhancer and PCAT1 promoter, thereby affecting the expression of PCAT1 which is involved in the development and progression of prostate cancer. |
| Pubmed ID | 30980423 |
| Year | 2019 |
| Title | SNPs in LncRNA genes are associated with non-small cell lung cancer in a Chinese population. |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |