Basic Information
LncRNA/CircRNA Name | BCAR4 |
Synonyms | NA |
Region | GRCh38_16:11819829-11828845 |
Ensemble | ENSG00000262117 |
Refseq | NR_024049 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | anti-estrogen,Cisplatin | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | qPCR, Luciferase reporter assay, Western blot |
Sample | colorectal cancer tissues,CRC cell lines (HCT-116, SW480, HCT-8) |
Expression Pattern | up-regulated |
Function Description | As expected, qRTPCR results showed BCAR4 expression was signifcantly up-regulated ,we found that BCAR4 was signifcantly upregulated in the ALDH+ cells and the expression level of BCAR4 was consistent with CD133 and SOX2 which were the markers of CSC in CRC. |
Pubmed ID | 30962766 |
Year | 2019 |
Title | LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer. |
External Links
Links for BCAR4 | GenBank HGNC NONCODE |
Links for colorectal cancer | OMIM COSMIC |