Basic Information
LncRNA/CircRNA Name | PCA3 |
Synonyms | PCA3, DD3, NCRNA00019, PCAT3 |
Region | GRCh38_9:76691980-76863307 |
Ensemble | ENSG00000225937 |
Refseq | NR_015342 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | prostate cancer |
ICD-0-3 | C61.9 |
Methods | Northern blot etc. |
Sample | prostate cancer tissues |
Expression Pattern | up-regulated |
Function Description | Differential display code 3 (DD3(PCA3)) is a novel gene with characteristics that indicate its potentially valuable role in early identification of malignancy and in the construction of interventions directed specifically toward malignantly transformed cells. DD3(PCA3) has a messenger RNA product that is highly overexpressed in tumors. Compared with other genetic markers that are associated with prostate tissue, DD3(PCA3) is the most specific marker for malignant disease. |
Pubmed ID | 14607216 |
Year | 2003 |
Title | New targets for therapy in prostate cancer: differential display code 3 (DD3(PCA3)), a highly prostate cancer-specific gene. |
External Links
Links for PCA3 | GenBank HGNC NONCODE |
Links for prostate cancer | OMIM COSMIC |